GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs10935120 | 1 | rs6806417 | chr3:134211446 | ANAPC13 | chr3:134196547-134204865:- | -0.62 | -6.95 | 4.58E-10 | Height |
| THYM | cis | rs10935120 | 1 | rs6806417 | chr3:134211446 | CEP63 | chr3:134204575-134293852:+ | -0.42 | -5 | 2.66E-6 | Height |
| THYM | cis | rs9815354 | 1 | rs6807015 | chr3:41754514 | ULK4 | chr3:41288091-42003660:- | 0.99 | 10.12 | 9.3E-17 | Diastolic blood pressure |
| THYM | cis | rs9876781 | 1 | rs6810060 | chr3:48434748 | TREX1 | chr3:48501186-48509043:+ | -0.28 | -4.38 | 3.06E-5 | Longevity |
| THYM | cis | rs1577917 | 1 | rs68171315 | chr6:86707400 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.96 | 4.28E-10 | Response to antipsychotic treatment |
| THYM | cis | rs2243480 | 1 | rs68189316 | chr7:65409169 | CCT6P1 | chr7:65216092-65228661:+ | 0.62 | 5.13 | 1.51E-6 | Diabetic kidney disease |
| THYM | cis | rs2273 | 1 | rs6827617 | chr4:76916146 | NAAA | chr4:76831809-76862166:- | -0.45 | -4.79 | 6.23E-6 | Longevity |
| THYM | cis | rs568617 | 1 | rs687672 | chr11:65649984 | CTSW | chr11:65647284-65651212:+ | 0.58 | 6.95 | 4.54E-10 | Crohn's disease |
| THYM | cis | rs568617 | 1 | rs687672 | chr11:65649984 | SNX32 | chr11:65601410-65621170:+ | -0.54 | -5.02 | 2.4E-6 | Crohn's disease |
| THYM | cis | rs10461617 | 1 | rs6885541 | chr5:56110857 | C5orf35 | chr5:56205103-56213010:+ | 0.74 | 8.92 | 3.44E-14 | Type 2 diabetes |
| THYM | cis | rs6911965 | 1 | rs6901703 | chr6:24475300 | GPLD1 | chr6:24428405-24489850:- | -0.46 | -4.69 | 9.22E-6 | Hematological and biochemical traits |
| THYM | cis | rs9369898 | 1 | rs6902429 | chr6:49393500 | CENPQ | chr6:49431096-49460820:+ | -0.3 | -5.65 | 1.67E-7 | Homocysteine levels |
| THYM | cis | rs6911965 | 1 | rs6910460 | chr6:24471712 | GPLD1 | chr6:24428405-24489850:- | 0.45 | 4.67 | 9.97E-6 | Hematological and biochemical traits |
| THYM | cis | rs6911965 | 1 | rs6911965 | chr6:24480295 | GPLD1 | chr6:24428405-24489850:- | -0.52 | -4.97 | 3.0E-6 | Hematological and biochemical traits |
| THYM | cis | rs1577917 | 1 | rs6914463 | chr6:86653415 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -7.62 | 1.9E-11 | Response to antipsychotic treatment |